Blender boolean system is getting better every version. However there are serious issues with highly complex meshes.
Thanks to the effort of a dental surgeon, a 3d designer and a software developer, this addon allows the integration of Blender and Cork - a powerful standalone boolean calculations software.
This addon was created in 2015 to help planning and executing osteotomy surgery procedures. Since then it was used in a series of projects involving orthognathic surgery simulations, and human and veterinarian prosthesis modelling.